Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation (2026)

[u/MBaggott]

https://www.science.org/doi/10.1126/science.aec6116

Editor’s summary: Chemotherapy-induced peripheral neuropathy (CIPN), one of the most debilitating side effects of some cancer therapies, is a painful condition with no known remedy and is thus a major cause of treatment discontinuation. Heles et al. reported that prophylactic treatment with the natural psychedelic psilocybin prevented the development of CIPN in mouse models (see the Perspective by Maiarú). Mechanistically, psylocibin acted both peripherally and centrally through two independent mechanisms: reducing pain perception and protecting peripheral sensory neurons. Psychedelics might offer an effective therapeutic approach for preventing CIPN. —Mattia Maroso

[u/AtypicalPreferences]

Fascinating! Wonder if it helps for other neuropathies

[u/Authentic_Power]

This is incredible

[u/AutoModerator]

Dear commenters,

You may be able to use Sci-Hub, LibGen or /r/scholar to remove barriers to your learning by allowing you to access this research. There is also the Sci-Hub Now extension for your browser.

You can use the "report" feature to remove this comment - just mark it as spam.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

[u/Super_Samus_Aran]

Dr. Thomas Seyfried, head of Boston College cancer institute for 40 years, has good information about cancer treatment. 

[u/Kalki_X]

A potential headline could be "Psychedelic fungus mitigates damage from egregious iatrogenic treatment" !