I've had anxiety all my life (trauma and other issues, no panic attacks though) in the form of worry thoughts, hypervigilance, social anxiety and OCD (OCD in remission due to CBT). I also have ADHD and I'm medicated for it with low-dose stimulants (no effect on my anxiety, just ADHD symptoms, on off days it's basically the same).

I've tried many OTC things for anxiety, l-theanine (mild help), saffron (no effect), silexan (no effect). Ashwaghanda did help but caused anhedonia after some time so i stopped that

Out of pharmaceuticals I tried a couple of SSRIs before my ADHD diagnosis and I remember having erectile dysfunction and being numbed out on them, but perhaps my anxiety was a bit better (I frankly don't remember well). However, my motivation was bad on them due to lack of ADHD treatment and the numbing effect of SSRIs so I had to stop them. Perhaps it would be more tolerable with ADHD meds.

i also tried benzos which were effective but I didn't end up using them long term due to dependence risks.

But now anxiety is becoming a persistent issue again and I'm not sure how to deal with it. i truly only feel quiet when I'm sleep deprived, when I'm well rested I always end up being anxious.

Are there any nootropics with anti anxiety effects for this kind of issue that are worth trying (such as selank) or are they pretty much useless for me? ideally I'd want something that doesn't have the flattening effects of SSRIs.

Or should I go straight to SSRIs?

I don’t really have social anxiety but I’m naturally pretty introverted and don’t really talk unless talken to, but Saffron literally changes my whole personality even in a single dose. I’m more talkative, more relaxed and confident I’d compare its effects to benzos, and trust me I’ve tried my share of gabaebics and benzos and I’d put Saffron on top of the list. What mechanic is it that it works so well on me? It’s actually amazing.

I’ve noticed when taking NAC, even if I take it at night, my meds don’t seem as effective the next day.

I obviously want my meds to be as effective as possible, but I also wanted to take advantage of the antioxidant benefits associated with NAC.

Has anyone found a workaround for this at all?

I've been sharing my weightloss side on a couple subs and got asked about the cognitive stuff, so here's the full rundown. n=1, no sourcing questions in the thread please, I won't answer them here.

Some background: I used to take ADHD medication. I'm off it now and wasn't on it at the same time as any of this. Not telling anyone to drop their meds, that was a decision I made with my own info.

One thing up front: I ran all four subq, including Semax and Selank. I know most people go nasal with those two. Subq is just what I had going and it worked for me, so I can't compare.

NAD+

The protocols out there are all over the place, so I started conservative. 10 mg in the morning and I felt it right away. Slight headache later in the day the first two times, then never again. Went to 15 mg over the next week, then 20, then 25 after a couple of months. Tried 30 when I was dragging but 25 is my happy medium. 5 days on, 2 off, and I still run it. Clean energy that gets me going almost immediately, no crash. I know people who feel nothing at 25 and do 50+ a few times a week, so the range is real.

Semax

This was the one I tried first because of the ADHD history. 333-500 mcg every morning. It worked, but mild. Noticeable, not dramatic. Ran it about a month.

Adamax

Switched to this after the month on Semax. 250 mcg Monday/Wednesday/Friday and I felt exceptionally locked in. Ran that for about 12 weeks. The interesting part was stopping: I felt less need for it and my baseline focus felt higher than before I started. Now I only use it as needed on a big day.

Honesty note: there is basically no published work on Adamax. It's sold as a Semax analog and everything you'll read about it, including this, is anecdote. Take it that way.

Selank

I don't personally have much anxiety, so this wasn't for that. I have a hard time turning my mind off at night. 333 mcg in the evening after dinner, as needed, and it calms the mind down and helps me relax. Really enjoy it.

Where I've landed

NAD+ dailyish, Adamax and Selank as needed, Semax retired. My takeaway from all four: there isn't a "right" way to do the cognitive peptides. Start low, change one thing at a time, and you'll find what works for you personally.

Curious about others experiences and what's worked and what hasn't for others, especially anyone who ran Semax and Adamax back to back.

Pgl chem us kind of expensive same as others like euro nootropic who have bad products

Recently started 200mg lamotrigine for treatment-resistant depression and possible bipolar spectrum features. It has been a godsend for me in all aspects of my life, except for recall and short-term memory (as well as coordination and balance, but I’m not too concerned about those). I also take 18mg of methylphenidate XR which helps a little bit.

Recently went back to school to work towards a two-year medical program. Paradoxically, I am much more motivated to study, and I’m studying for much longer periods without burning out. However, complex material and vocabulary seem to slip right through my fingers sometimes. I’m taking tests and getting Bs while I know with the amount of studying I’m doing I should be getting As.

Someone here mentioned piracetam as something that can counteract these recall and memory issues. I was wondering if anyone has experience with this nootropic or others for mood stabilizer-induced cognition issues.

TIA!

Started to use MPEP Oxalate recently, looking to quit smoking weed and Adderall. MPEP seeks to be a neuroprotective and anti-addtictive compound. Started with 40 mg passed, 8 days passed, worked quite good, without any relapse. I’m bulding a new stack right now, I give up Adderall but adding Fasoracetam and Bromantane. Still working nice, hope it continues like this.

The official research seems compelling so I am interested in anecdotes.

I am a pretty healthy 30 year old female, maybe slightly above average fitness. doing pretty well physically, but mentally I have been dealing with exhausting obsessive thinking since adolescence.

Good sleep hygiene and getting even a modest amount of exercise a few times a week has probably done more for me than any supplement could, so obv I will prioritize this.

Trust me it works really really well. 28mg Affron capsules

At 20 I was given an ssri sertraline I think and will be 30 in November now and I tried removing the trash 5 times now and every time more crap was mixed in. Been on most SSRIs, both SNRIs, lamotrigine, pregabalin, risperidone, aripiprazole, agomelatine, vortioxetine, others I forgot.

Currently on bupropion 300 mg XL and 5 mg escitalopram. On the 6th taper attempt, I was tapering for the fifth time before and I ended up bed ridden and other host of problems and have been 99 percent stuck in my apartment for the past 4 months and counting.

This time this will be the sixth attempt for remove this trash. But I already feel bad since this is a whole tablet removal every few days taper each week.

Not sure what to do. Being home and not being able to do anything with the apathy and not enjoying anything is bad. Just been forcing myself to play marvel rivals and i need to recover to save my job.

Lost my gym physique for the millionth time as well..... Life is pointless..... No basic needs ofcourse either but I focused on the foundation of living which was consuming media and self improvement, mostly by training in the gym.

Would appreciate advice since my life has been destroyed and I feel so bad and hate the days.

Hi, I just received my roder of bromantane nasal spray and Tak-653 in capsule form (2mg), before going to class didn't have time to take bromantane, but I did take tak the capsule. But I want to ask how to dose weekly, I'm an EE student and I'm trying to max my studying and learning process. I also have alpha gpc and uridine and I might get L-tyrosine. Should i take both tak 653 and bromantane at the same time and what effects should i see and the dosage of course.

Hi, I'm new and have been thinking about looking into nootropics for academic support, and anxiety reduction, specifically CDP Choline, Selank/Semax Spray, and Aniracetam. Could you recommend any resources for first getting into this space / getting started with nootropics, as well as your thoughts on the compounds above specifically (If there are better alternatives that you recommend). Finally, are there any reputable suppliers that don't have issues with shipping to the UK. Thank you.

Hi! Where is everyone getting their Bromantane in North America right now?
Looking for the best quality available.
Also, any Canadians here who successfully get it shipped without customs/Health Canada seizing it? Let me know your go-to vendors.

Night #1 I did a single spray(100mcg) and waited to see what happened. Nothing, so I did another spray a couple hours later. Evening went fine. Night #2 I did a single spray in each nose at the same time. Later in the night I noticed feeling a little overstimulated and irritable. Increased anxiety. Similar to the way to way THC(anything more than 5mg), muscle relaxers(cyclo, tinaz), and benzos(anything more than .5mg Xanax/kpin) have made me feel. Night #3 I just went back to one spray only. Still felt off, and sleep was definitely worse. Night #4 just a single spray again. But this time it was noticeably elevated heart rate(probably 100-110), racing thoughts, increased anxiety, etc. Absolutely terrible sleep. Woke up twice from night terrors. Haven't taken it since and none of those symptoms came back.

I'm confused as to why the first night with 2 sprays didn't cause these effects, but the subsequent days did. Even when I only did a single spray. Has anyone else had a similar experience?

I just need someone who has tried this nootropic to tell me a bit about their experience—what they used it for or how they utilized it—so I can form my own opinion.

I’m looking for feedback from people who have personally used yohimbine HCl (yohimbine hydrochloride) for sexual improvement or to deal with sexual problems.

I’m specifically interested in yohimbine HCl, not yohimbe bark or a generic yohimbe supplement.

If you’ve tried it, I’d especially like to know whether you noticed any of the following:

• Did it make you reach ejaculation/orgasm faster?
• Did it increase penile sensitivity or sexual sensation?
• Did it make orgasms feel stronger or easier to reach?
• Did it improve erection strength or quality?
• Did it increase arousal or libido?
• Did it have no sexual effect at all, or make anything worse?

I’m aware of the potential side effects people report with yohimbine, including anxiety, increased heart rate, blood-pressure changes, sweating, agitation, etc. I’m not looking for reassurance about safety here—I’m mainly trying to collect real-world experiences about its sexual effects.

If you’ve used it, please include as much of this as you can:

• Dose you took
• Whether you took it once before sexual activity or every day
• If taken before sex/masturbation, how long beforehand
• Whether you took it fasted or with food
• How often you used it and for how long
• What sexual problem or improvement you were trying to address
• What benefits you actually noticed
• Any side effects
• Whether you were taking an SSRI or other medication at the time, if relevant

I’m also very interested in hearing from people who tried yohimbine HCl and got no benefit, because knowing the unsuccessful doses/protocols is just as useful as hearing success stories.

I’m trying to get a clearer picture of what people have actually experienced with yohimbine HCl specifically for sexual function.

Modafinil is usually the first nootropic people hear about when they start getting into this space, and thats for good reason. I tried 200mg at around 8:00am for peak strength once I’m ready to settle down and do my work.
At around 9:00ish, I could already feel the effects kicking in. Just doing some work on the computer I felt so energetic but not the kind that makes you antsy and jump around, but the kind that makes you focused on whatever you’re doing at that time and only then. It was smooth uphill after that. Email after email, paperwork after paperwork, I felt like I’d finally found my limitless pill.

Then around the 3:00 mark of ingestion, (11:00) noise of everything started coming through, no more filtering. If I was listening to music while doing my work, I was no longer working. I was trying to find more songs to add in my playlist that were similar to the one I was currently listening to.
It didn’t feel like I could work until everything by was set, meaning I started cleaning my room instead of doing my work. As productive as it sounds, not what my goals were at the time.

At around 4:00 post ingestion, (12:20ish) I didn’t get the huge drop off everyone talks about. I just felt adequate. Having enough in me to do my work, but taking the occasional breaks when I felt overwhelmed; I didn’t have the motivation to tackle it all at once. At the end of the day almost every day, I’m normally pretty tired and struggle even making it upstairs. This time though, I felt like I could go on a little longer. Squeezed in a bit extra work just to take a Load off for tomorrow. Had a little bit of trouble sleeping, 8:00 is kind of the cut off to take it I’d say.

My overall experience: 8/10 I was focused, energetic, and didn’t get the crash or really any other adverse side effects that are most commonly spoken of. Many people say modafinil is simply a wakefulness drug and nothing else. They most likely don’t have the correct enzyme alterations to metabolize it efficiently. If you were interested about using modafinil, you have the right idea.

Hi, has anyone tried MIF-1 for mainly chronic, long-term anxiety problems (such as GAD), constant ruminations, low mood/motivation or depression?

I’m thinking about giving it a try and ordering it from a reputable vendor, but one nasal spray costs around €200, so I'm trying to figure out if it's even worth experimenting with.

I’ve been on various psychiatric medications for around 15 years without any noticeable long-term improvement, and I’m still on medication now.

I also tried Selank before, but it didn’t help my anxiety and caused insomnia at night.

Would be interested in any actual experiences, positive or negative. Thanks

What can i do against the mental crash on stimulants,I’ve tried switching to other stimulants and lowering the dose but nothing helps does somebody know how to reduce the crash or prevent it?

So basically as the title says, im looking for a short acting stimulant (or any other nootropic that would help learn maths) that i could take at 3pm or so, and still be able to sleep at a reasonable hour. Im excluding the most obvious answer which is nicotine, as im a nicotine addict, actually trying to put it down. Girlfriend is out of town so i can go through the withdrawals peacefully without going absolutely nuts on her lol. Caffeine doesnt do much to me so im looking for some less known options. Id really aprreciate any help from you guys🙌🙌

I dont even feel the top of my brain anymore that sensation is gone.

I am scared of side effects. But also my quality of life needs help with a smarter more intelligent brain.

American psychiatry has no real regenerative medicines!!!

Sleep 8-10 hours, originally thought I had sleep apnea, got a full lab study, basically told me my sleep quality is garbage but no apnea.

Modafinil is fine but makes my sleep quality even worse..

What can I do?

Hey everyone , I'm in the EU and I'm looking for feedback on the Semax nasal spray from Euro Nootropics. It's Semax Acetate, 10 mL, 20 mg total, and the label says 2 mg per spray.

The dosing seems weird to me: 2 mg per spray sounds huge compared to the usual 600 mcg that people often mention. Can someone explain this dosage to me - is it normal?

I'm quitting nicotine and probably starting non stimulant ADHD meds next month (I had to run out of the psychiatrist before I got around to discussing options for another commitment) so have about a month before I start actual ADHD meds. I'm looking into saffron, bromatane or semax/selank to try out. I'm wondering if anyone has better suggestions?

Any experience researching Adamax on your lab rats? I currently have a Adamax 1032 nasal spray 150mcg/spray that I’m going to try on my lab rat. Any experience or advice highly appreciated thank you