will combining light doses of baclofen (25ish mg) with pregabalin (300-600mg) pose a major CNS depression risk? have no experience with baclofen, not planning on mixing with pregabalin until i know how i handle it.

What is the most euphoric GABAergic drug that is known today. I have mostly heard about GHB/ GBL beeing the Most euphoric one but is this true or are there more euphoric GABAergics? Dont care if GABA A, GABA B or even gabapentinoids

Hey guys, I have 1800mg(6-300mg capsules) of gabapentin right now. I’m just wondering if that would be enough, and is taking it every 30 or 45 minutes better? I’m going to take 300mg right now and I’ll update in a bit!

Does anyone else calls their pregabs Gabagool? Usual interaction with my friends is when they bring pregabs to a hangout and you tell them “Gabagool! Ova’ here! What’d ya hear what’d ya say!”

We can’t be the only ones?

Hello fellow gaba enjoyers! For the last one and a half years i ve been using GABA drugs quite oftet and that got me wondering how much damage if any i do to my body.
I use gabapentin like 3-4 times a week (1500mg on average) and sometimes i take baclofen or pregabalin, also xanax but on a very rare occasion like twice a month.
And i ve been doing it for quite a while as i said, but occasionally i have 3-4 weeks breaks from everything and i dont feel any withdrawals or cravings, just some trouble falling asleep but that lasts few days max.
So what do you think guys? Am i good or should i reduce my usage?

I'm kind of new to this so I'm wondering if it's in my head, but I don't feel like I get anything out of staggering gabapentin every 30 minutes. I've tried staggering and taking it all at once and it seems like I get more effects from all at once but it does wear off faster. Is the main benefit of staggering longer legs? Anyone else prefer not to stagger or am I just doing it wrong?

I'm currently pretty much , well definitely dependant on 3 gabas and have been for a couple years, I'm probably there with pregabs too making it 4 (this isn't a flex btw life this way isn't actually life)

I'm going to my 3rd detox in a week or so and I'm curious if anyone is willing to let me know what madness they have ran in the past because I technically know I'm doomed but would like to know how doomed as my doc keeps saying ' it will be tough but all good now bother'

TIA

What’s the sweet spot for this stuff? I’ve done this much before but I never considered that maybe less is more? Did I pass up the dose that actually feels really good?

I be floating feeling real good. This stuff bangs fr. What's crazy is I wasn't even expecting to get it, my usual supplier sent me a surprise package due to messing up my last order. Love it

Yesterday I took 600mg and am planning to take Pregabalin again on the 2nd day which is today. If I take 300mg or 450mg, will I still feel the effects?

Which one do you prefer? What are the biggest differences in effects and will I like it if I love pregabalin and GHB

Best amount to combat them the next day after?

I take 150mg pregab occasionally for anxiety reasons, but I only take it maybe twice a month because I don’t much about it. Can anyone be honest with me and tell me how often I can take 150mg pregab and get away with it with no problems?

Title. Recently switched from gabapentin to pregabalin and I wondered if the usual rules of thumb applied (I.e. fatty meal, staggered doses).

Three of my favorite drugs are Pregabalin, Gabapentin and Baclofen. They make me feel like flying.
Except. I absolutely can’t orgasm.

Anyone else?

I’ve seen a lot of conflicting opinions. Some people say they increase the effects of pregabalin, while others say they decrease them.

The way I see it—since both are glutamate blockers—wouldn't that actually intensify the effects? Would taking agmatine on days when I don't take pregabalin help reduce tolerance? Thanks.

I don't have access to regular IR gaba anymore but my doctor wrote me 300 mg extended release gaba called Conventin XR (or Gralise in the US.)

It just hit me that it is a film coated tablet, and that if I split it that would break the extended release mechanism.

So if I split it, can I use it recreationally? And has any of you done this before or experienced it?

Thanks!

Blehhh

Currently tapering from a 300-600mg pregabalin a day habit. I feel like shit.

Can withdrawal cause long lasting trauma in someone?

(wanted to clarify aswell: i talk about agmatine which isn’t approved as a supplement, based on studies it doesn’t seem to be harmful at doses studied but always do your own research. Also i don’t think it’s been studied long term so just keep that in mind)

This is a weird ass discovery I made and i actually thought this only applied to gabapentin but it works really well for Lyrica suprisingly. For some context, I am on 350mg of pregabalin daily for anxiety, used to be on 550mg

I’ve tested this method with and without agmatine in the mix and i find agmatine actually really adds to this effect.

It kicks in about 2x faster and arguably harder.. You make sure you have a relatively empty stomach then take your 500-1000mg agmatine 15-30 mins before, then you take your pregabalin dose with a carbonated drink. I’ve tested sugary drinks and non-sugary drinks and I find it doesn’t really matter but generally if it’s a bit acidic I find that helps a bit? (can’t really find any evidence to support pH affects it)

Pregabalin is absorbed through LAT1 (an amino acid transporter) in your upper intestine, this means it can’t dissolve in your stomach and the faster it can leave your stomach the better. Now obviously that means a empty stomach is better, but to do even more would be drinking a carbonated drink on top of a empty stomach, the dissolved carbon dioxide creates pressure within your stomach (which creates a physiological response to push stomach contents into your intestines faster) and it also dilates blood vessels in your intestines which lets pregabalin dissolve faster (this dilation is also way more pronounced with agmatine, a releaser of endogenous nitrogen monoxide)

I also believe the carbonation + increased pH may probably affect how fast the capsule dissolves too (not fully sure on this)

Yeah just wanted to share my discovery, helps a lot when my anxiety is getting bad and need the dose to hit me quickly. 😁

A while back ago I was asked to sign my name while I was on pregabalin and... My handwriting was terrible.

I couldn't write my damn name properly and I was definitely acting sus af. ✍️🏼👁️✍️🏼👁️✍️🏼👁️✍️🏼

Do y'all's motor skills become poor on pregabalin too?

Like how much to wait?

Is it any good?

Hi guys. A couple of weeks ago I started taking pregabalin. I usually take 200-250 mg twice a week - on Mondays and Fridays. I am afraid of developing tolerance taking it more than once a week. Should I be worried?

Would be really grateful for your advice!

Wanna mix them, don’t know how to make it right. Pls help. I’m not a stonner, just occasional